The goal of this analysis was to identify bone density values and additional potential contributors to sustained BMD loss in women receiving RT, with or without chemoradiotherapy, for cervical cancer.
#Stata MP 16.0 Serial Number trial#
17 Here we report results of a secondary analysis of that prospective trial to explore longitudinal changes in BMD in vertebral bodies within and outside the RT fields.
![Stata MP 16.0 Serial Number Stata MP 16.0 Serial Number](https://data.princeton.edu/stata/stata16.png)
001), and BMD in the lumbar spine, femoral neck, and hip were all significantly decreased after RT relative to before. 17 In that study, osteoporosis before treatment was a major predictor of pelvic fracture (hazard ratio, 11.06 P <. We previously conducted a prospective study to characterize the changes in BMD that occur after RT for gynecologic malignancies. 13 The reported prevalence of pelvic fracture after pelvic RT for cervical cancer ranges from 10% to 61%.14, 15, 16 However, the patterns and mechanisms underlying changes in BMD and the relationship between sites of BMD loss and the location of RT fields have not been explored. 12 The nonspecific presentation of pelvic insufficiency fractures, which include symptoms such as lower back pain, may also delay diagnosis. 10, 11īone density evaluations of the lumbar spine and pelvis are not routinely performed for women younger than 65 years of age, a practice that hinders early detection of BMD loss. 9 Corticosteroids, often given to reduce the emetogenicity of chemotherapy, also have been known to decrease osteoblast activity and bone density when taken chronically. 6, 7 Chemotherapy can also contribute to decreased BMD among premenopausal women, either indirectly through loss of ovarian function or directly via bone remodeling. 8 Pelvic RT not only induces early menopause, which causes BMD loss, but also increases BMD loss by suppressing osteoblast proliferation, which can contribute to additional bone density loss. 6, 7 As a result, collateral doses of radiation to bone tissue may reduce bone volume and bone marrow stem cell populations. However, exposure to RT has been associated with reduced proliferation of osteoblasts and devascularization of bone tissue, both of which inhibit the building and strengthening of bone matrix. Radiation therapy (RT) is a highly effective and widely used curative modality for treating malignancies. 3, 4 Reductions in bone mineral content and elastic resistance in pelvic bones can lead to osteoporotic stress fractures these are most prevalent among postmenopausal women. 1, 2Īge, menopausal status, body mass index (BMI), and bone marrow microenvironment (ie, osteoblast numbers) are known factors that drive BMD levels.
![Stata MP 16.0 Serial Number Stata MP 16.0 Serial Number](https://pcwonderland.com/wp-content/uploads/2018/10/StataCorp-Stata-MP-15-3.jpg)
Pelvic insufficiency fractures resulting from loss of bone mineral density (BMD) can result in significant health burdens, including loss of mobility and increased morbidity and mortality.